Speculation is all we have for many aspects of this pandemic, but the speculations at least needs to make sense. The suggestion that we may already have 50 to 100 times the Coronavirus cases as being reported means in the US that would be 15–30 million. At that point population immunity becomes relevant, especially in hard hit areas. The surge of new cases over time is what happens in an immunologically naive population. I fear this is what we are in for. Widespread application of antibody testing is what is needed to determine the immunologic “experience” of a population. This could be deployed in Seattle and NYC, using random sampling processes, to determine how pervasive the infection has been in areas where there have been lots of sick people. That is the key information we need to consider relaxing restrictions and preparing for new waves of cases.